And he concludes that it’s a cumulative risk.

Dr. Charles explained that diphenhydramine is an antihistamine commonly used for allergic reactions.

“One of the major side effects of antihistamines (like Benadryl) is drowsiness.

Close-up of Puza in the video

This side effect is now being utilized as a sleep aid.

In the short term, antihistamines are safe and well tolerated.

They are used commonly in dermatology, allergy clinics, and internal medicine,” he shared.

Gloved hand pointing to brain scans

“Taking these as sleep aids short-term feels like safe.

However, when taken every night for sleep, were seeing associations with dementia*,” he said.

And he isn’t sure what specific ingredient may be linked to dementia.

Close-up of Pugh recommending other sleep strategies, like eye masks and a weighted blanket

“As for why this OTC medicine is associated with dementia, we may never find out.

So why aren’t these risks being disclosed more openly?

“And I would caution against any long-term sleep aid,” he added.

Pugh in a white doctor's coat and arms folded

“I like to recommend a winding-down routine to my patients,” he said.

“No screentime, no caffeine, no alcohol.”

Close-up of pink tablets emerging from a bottle

A person sleeping in bed with a glass of water and a pill bottle on the night table

Blue pills on a surface

Blurry photo of someone resting and a brain scan next to them

Pills being dispensed in a laboratory

Charles Puza in a suit and tie